Comparison of Infant Gut and Skin Microbiota, Resistome and Virulome Between Neonatal Intensive Care Unit (NICU) Environments
Identifieur interne : 000E34 ( Main/Exploration ); précédent : 000E33; suivant : 000E35Comparison of Infant Gut and Skin Microbiota, Resistome and Virulome Between Neonatal Intensive Care Unit (NICU) Environments
Auteurs : Suchitra K. Hourigan [États-Unis] ; Poorani Subramanian [États-Unis] ; Nur A. Hasan [États-Unis] ; Allison Ta [États-Unis] ; Elisabeth Klein [États-Unis] ; Nassim Chettout [États-Unis] ; Kathi Huddleston [États-Unis] ; Varsha Deopujari [États-Unis] ; Shira Levy [États-Unis] ; Rajiv Baveja [États-Unis] ; Nicole C. Clemency [États-Unis] ; Robin L. Baker [États-Unis] ; John E. Niederhuber [États-Unis] ; Rita R. Colwell [États-Unis]Source :
- Frontiers in Microbiology [ 1664-302X ] ; 2018.
Abstract
Url:
DOI: 10.3389/fmicb.2018.01361
PubMed: 29988506
PubMed Central: 6026636
Affiliations:
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Hourigan</name><affiliation wicri:level="1"><nlm:aff id="aff1"><institution>Department of Pediatrics, Inova Children’s Hospital, Falls Church</institution>,<addr-line>VA</addr-line>,<country>United States</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff2"><institution>Inova Translational Medicine Institute, Falls Church</institution>,<addr-line>VA</addr-line>,<country>United States</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff3"><institution>Department of Pediatric Gastroenterology, Pediatric Specialists of Virginia, Fairfax</institution>,<addr-line>VA</addr-line>,<country>United States</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Subramanian, Poorani" sort="Subramanian, Poorani" uniqKey="Subramanian P" first="Poorani" last="Subramanian">Poorani Subramanian</name><affiliation wicri:level="1"><nlm:aff id="aff4"><institution>CosmosID, Rockville</institution>,<addr-line>MD</addr-line>,<country>United States</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Hasan, Nur A" sort="Hasan, Nur A" uniqKey="Hasan N" first="Nur A." last="Hasan">Nur A. Hasan</name><affiliation wicri:level="1"><nlm:aff id="aff4"><institution>CosmosID, Rockville</institution>,<addr-line>MD</addr-line>,<country>United States</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Ta, Allison" sort="Ta, Allison" uniqKey="Ta A" first="Allison" last="Ta">Allison Ta</name><affiliation wicri:level="1"><nlm:aff id="aff1"><institution>Department of Pediatrics, Inova Children’s Hospital, Falls Church</institution>,<addr-line>VA</addr-line>,<country>United States</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Klein, Elisabeth" sort="Klein, Elisabeth" uniqKey="Klein E" first="Elisabeth" last="Klein">Elisabeth Klein</name><affiliation wicri:level="1"><nlm:aff id="aff2"><institution>Inova Translational Medicine Institute, Falls Church</institution>,<addr-line>VA</addr-line>,<country>United States</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Chettout, Nassim" sort="Chettout, Nassim" uniqKey="Chettout N" first="Nassim" last="Chettout">Nassim Chettout</name><affiliation wicri:level="1"><nlm:aff id="aff2"><institution>Inova Translational Medicine Institute, Falls Church</institution>,<addr-line>VA</addr-line>,<country>United States</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Huddleston, Kathi" sort="Huddleston, Kathi" uniqKey="Huddleston K" first="Kathi" last="Huddleston">Kathi Huddleston</name><affiliation wicri:level="1"><nlm:aff id="aff2"><institution>Inova Translational Medicine Institute, Falls Church</institution>,<addr-line>VA</addr-line>,<country>United States</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Deopujari, Varsha" sort="Deopujari, Varsha" uniqKey="Deopujari V" first="Varsha" last="Deopujari">Varsha Deopujari</name><affiliation wicri:level="1"><nlm:aff id="aff2"><institution>Inova Translational Medicine Institute, Falls Church</institution>,<addr-line>VA</addr-line>,<country>United States</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Levy, Shira" sort="Levy, Shira" uniqKey="Levy S" first="Shira" last="Levy">Shira Levy</name><affiliation wicri:level="1"><nlm:aff id="aff2"><institution>Inova Translational Medicine Institute, Falls Church</institution>,<addr-line>VA</addr-line>,<country>United States</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Baveja, Rajiv" sort="Baveja, Rajiv" uniqKey="Baveja R" first="Rajiv" last="Baveja">Rajiv Baveja</name><affiliation wicri:level="1"><nlm:aff id="aff5"><institution>Fairfax Neonatal Associates PC, Falls Church</institution>,<addr-line>VA</addr-line>,<country>United States</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Clemency, Nicole C" sort="Clemency, Nicole C" uniqKey="Clemency N" first="Nicole C." last="Clemency">Nicole C. Clemency</name><affiliation wicri:level="1"><nlm:aff id="aff2"><institution>Inova Translational Medicine Institute, Falls Church</institution>,<addr-line>VA</addr-line>,<country>United States</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Baker, Robin L" sort="Baker, Robin L" uniqKey="Baker R" first="Robin L." last="Baker">Robin L. Baker</name><affiliation wicri:level="1"><nlm:aff id="aff5"><institution>Fairfax Neonatal Associates PC, Falls Church</institution>,<addr-line>VA</addr-line>,<country>United States</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Niederhuber, John E" sort="Niederhuber, John E" uniqKey="Niederhuber J" first="John E." last="Niederhuber">John E. Niederhuber</name><affiliation wicri:level="1"><nlm:aff id="aff2"><institution>Inova Translational Medicine Institute, Falls Church</institution>,<addr-line>VA</addr-line>,<country>United States</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Colwell, Rita R" sort="Colwell, Rita R" uniqKey="Colwell R" first="Rita R." last="Colwell">Rita R. Colwell</name><affiliation wicri:level="1"><nlm:aff id="aff4"><institution>CosmosID, Rockville</institution>,<addr-line>MD</addr-line>,<country>United States</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author></analytic><series><title level="j">Frontiers in Microbiology</title><idno type="eISSN">1664-302X</idno><imprint><date when="2018">2018</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p><bold>Background:</bold> There is a growing move to provide care for premature infants in a single family, private room neonatal intensive care unit (NICU) in place of the traditional shared space, open bay NICU. The resultant effect on the developing neonatal microbiota is unknown.</p><p><bold>Study Design:</bold> Stool and groin skin swabs were collected from infants in a shared-space NICU (old NICU) and a single-family room NICU (new NICU) on the same hospital campus. Metagenomic sequencing was performed and data analyzed by CosmosID bioinformatics software package.</p><p><bold>Results:</bold> There were no significant differences between the cohorts in gestational age, length of stay, and delivery mode; infants in the old NICU received significantly more antibiotics (<italic>p</italic> = 0.03). Differentially abundant antimicrobial resistance genes and virulence associated genes were found between the cohorts in stool and skin, with more differentially abundant antimicrobial resistance genes in the new NICU. The entire bacterial microbiota analyzed to the genus level significantly differed between cohorts in skin (<italic>p</italic> = 0.0001) but not in stool samples. There was no difference in alpha diversity between the two cohorts. DNA viruses and fungi were detected but did not differ between cohorts.</p><p><bold>Conclusion:</bold> Differences were seen in the resistome and virulome between the two cohorts with more differentially abundant antimicrobial resistance genes in the new NICU. This highlights the influence that different NICU environments can have on the neonatal microbiota. Whether the differences were due to the new NICU being a single-family NICU or located in a newly constructed building warrants exploration. Long term health outcomes from the differences observed must be followed longitudinally.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Bi, R" uniqKey="Bi R">R. Bi</name></author><author><name sortKey="Liu, P" uniqKey="Liu P">P. Liu</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Boyle, E M" uniqKey="Boyle E">E. M. 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Baker</name><name sortKey="Baveja, Rajiv" sort="Baveja, Rajiv" uniqKey="Baveja R" first="Rajiv" last="Baveja">Rajiv Baveja</name><name sortKey="Chettout, Nassim" sort="Chettout, Nassim" uniqKey="Chettout N" first="Nassim" last="Chettout">Nassim Chettout</name><name sortKey="Clemency, Nicole C" sort="Clemency, Nicole C" uniqKey="Clemency N" first="Nicole C." last="Clemency">Nicole C. Clemency</name><name sortKey="Colwell, Rita R" sort="Colwell, Rita R" uniqKey="Colwell R" first="Rita R." last="Colwell">Rita R. Colwell</name><name sortKey="Deopujari, Varsha" sort="Deopujari, Varsha" uniqKey="Deopujari V" first="Varsha" last="Deopujari">Varsha Deopujari</name><name sortKey="Hasan, Nur A" sort="Hasan, Nur A" uniqKey="Hasan N" first="Nur A." last="Hasan">Nur A. Hasan</name><name sortKey="Hourigan, Suchitra K" sort="Hourigan, Suchitra K" uniqKey="Hourigan S" first="Suchitra K." last="Hourigan">Suchitra K. Hourigan</name><name sortKey="Hourigan, Suchitra K" sort="Hourigan, Suchitra K" uniqKey="Hourigan S" first="Suchitra K." last="Hourigan">Suchitra K. Hourigan</name><name sortKey="Huddleston, Kathi" sort="Huddleston, Kathi" uniqKey="Huddleston K" first="Kathi" last="Huddleston">Kathi Huddleston</name><name sortKey="Klein, Elisabeth" sort="Klein, Elisabeth" uniqKey="Klein E" first="Elisabeth" last="Klein">Elisabeth Klein</name><name sortKey="Levy, Shira" sort="Levy, Shira" uniqKey="Levy S" first="Shira" last="Levy">Shira Levy</name><name sortKey="Niederhuber, John E" sort="Niederhuber, John E" uniqKey="Niederhuber J" first="John E." last="Niederhuber">John E. Niederhuber</name><name sortKey="Subramanian, Poorani" sort="Subramanian, Poorani" uniqKey="Subramanian P" first="Poorani" last="Subramanian">Poorani Subramanian</name><name sortKey="Ta, Allison" sort="Ta, Allison" uniqKey="Ta A" first="Allison" last="Ta">Allison Ta</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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